In the small, quaint town of Mumford, Dr. Mumford (LOREN DEAN) may have only beenthere for four months, but his psychology practice is already the most popular around. Although his curt, no- nonsense approach may seem unorthodox, he has many loyal patients, including pharmacist Henry Follett (PRUITT TAYLOR VINCE), who never accurately portrays himself in his film noir fantasies, and Althea Brockett (MARY McDONNELL), whose mail order obsession has her investor husband, Jeremy (TED DANSON), and their children, Martin (JASON RITTER) and Katie (ELISABETH MOSS), concerned about her.
Then there's Sofie Crisp (HOPE DAVIS), whose lethargic depression has forced her to move back in with her parents, rebellious teenager Nessa Watkins (ZOOEY DESCHANEL), and local modem king and multibillionaire, Skip Skipperton (JASON LEE), who believes he harbors a perverted secret.
Of course, not everyone is happy with Mumford's approach, and one disgruntled patient, Lionel Dillard (MARTIN SHORT), sets out to ruin the psychologist's career. Meeting with the town's other "shrinks," Dr. Phyllis Sheeler (JANE ADAMS) and Dr. Ernest Delbanco (DAVID PAYMER), Lionel begins to raise doubts about Mumford's credentials.
As time wears on, Mumford -- who spends his off-time watching the TV program, "Unsolved Mysteries" when not hanging out with Lily (ALFRE WOODARD), his landlady who's given up on men — realizes he must not only deal with the rising doubts about his practice, but also with his attraction to one of his clients and the fact that her harbors his own deep, dark secret.