In the deep reaches of space, the medical emergency rescue ship Nightingale receives a distress call from an abandoned lunar mining colony across the galaxy. Due to the extreme distance they must travel, Captain A.J. Marley (ROBERT FORSTER) orders that the ship and her crew, including co-pilot Nick Vanzant (JAMES SPADER) and Chief Medical Officer Kaela Evers (ANGELA BASSETT), go through a dimension jump. While a proven method of quickly traveling across space, it's also quite dangerous.
That point is proven when the Nightingale materializes in the strong gravitation pull of a star preparing to go supernova, and Marley is killed due to a fault in his safety pod. Having to take control, and with a stoic demeanor, Vanzant manages to save the ship and the rest of the crew -- that includes Benjamin (WILSON CRUZ), Yerzy (LOU DIAMOND PHILLIPS) and Danika (ROBIN TUNNEY) - from crashing into the lunar surface.
Even so, he's told by the ship's computer, nicknamed Sweetie, that they'll only have a margin of eleven minutes in between the moment when they'll be able to jump through space again and before the star goes supernova. Things become even more complicated when the crew picks up the sole survivor from the moon, Troy Larson (PETER FACINELLI), the apparent son of a man Kaela once knew intimately.
Troy admits to directly contacting the Nightingale for help and the crew begins to wonder about him and a strange alien artifact he possesses. As the crew becomes intrigued by Troy's odd biological makeup and begins to more closely examine the radiant artifact, they soon realize they've picked up far more than they bargained for. With time running out and discovering that they have a maniac of sorts on their hands, Vanzant and his crew do what they can to survive and get the ship out of harm's way.