Catherine Deane (JENNIFER LOPEZ) is a psychotherapist who's been experimenting with a unique way of bringing comatose patients out of their state. With the aid of fellow scientists, Dr. Miriam Kent (MARIANNE JEAN-BAPTISTE) and Henry West (DYLAN BAKER), Catherine has been making experimental journeys into the mind of Edward Baines (COLTON JAMES), a young boy who's been in a coma for the past eighteen months.
Utilizing their neurological synaptic transfer system, Catherine enters the boy's mind where, in a bizarre, dream-like world, she tries to gain his confidence and bring him back to consciousness. Knowing full well that her body will follow and react to whatever her mind experiences, the team has equipped Catherine with a transmitter chip in her hand that, when activated, aborts the latest cerebral journey.
During this time, serial killer Carl Stargher (VINCENT D'ONOFRIO) has been busy at work, abducting more victims - all pretty young women - and making them his real-life, doll-like playthings before ultimately drowning them in a large, enclosed cell. FBI Agents Peter Novak (VINCE VAUGHN) and Gordon Ramsey (JAKE WEBER) have been working the case, and eventually get their break when evidence leads them to Stargher's home.
Unfortunately, he's slipped into a viral-based coma from which doctors don't believe he'll ever recover, meaning that the FBI doesn't know the location of his latest victim, Julia Hickson (TARA SUBKOFF). Having seen videotapes of Carl's handiwork, they realize that Julia will soon drown in his hidden, but completely automated tank system if they can't locate and then rescue her.
As such, and hearing about Catherine's work, they decide to enlist her help. Although initially reluctant, she eventually agrees and soon travels into the twisted, surrealistic and definitely nightmarish world of Carl's subconscious mind. Meeting a boyish and still innocent version of the psychopath (JAKE THOMAS), Catherine does what she can to earn his trust and discover Julia's whereabouts, all before time runs out for her and while dealing with the various and dangerous adult versions of Carl who exist within his head.