Needing to win three of their last four games of the regular season to make the professional football league playoffs, the Washington Sentinels seem to have a good chance, especially considering that their quarterback, Eddie Martel (BRETT CULLEN), is one of the best in the league. Yet, a players' strike suddenly has team owner Edward O'Neil (JACK WARDEN) scrambling for options.
As such, he hires veteran coach Jimmy McGinty (GENE HACKMAN) to round up a team of replacement players to finish out those last four games. Although initially reluctant, McGinty eventually agrees and sets out after his first choice for quarterback, Shane Falco (KEANU REEVES), a one-time college sensation who disappeared after a debacle at the Sugar Bowl several years earlier.
Falco, who makes a living scraping barnacles off others' boats, is also reluctant, but sensing one last shot at the big time, he also agrees. Among his new teammates is Clifford Franklin (ORLANDO JONES), a fast but butterfingered receiver; Daniel Bateman (JON FAVREAU), a near psychotic and extremely intense cop; Nigel Gruff (RHYS IFANS) a chain-smoking Welsh soccer player; and Earl Wilkinson, a.k.a. "Smith" (MICHAEL JACE), who's been serving time in a Maryland prison.
Then there's born-again Christian Walter Cochran (TROY WINBUSH); music industry bodyguards,
Jamal (FAIZON LOVE) and Andre Jackson (MICHAEL "BEAR" TALIFERRO); Jumbo Fumiko (ACE YONAMINE), a former sumo wrestler, and Brian Murphy (DAVID DENMAN), a sensational tight end who happens to be deaf.
With little time to prepare and practice, let alone build any sort of team chemistry, the ragtag group of players must overcome their differences, the taunting and threats from the striking pro players, and the distractions posed by head cheerleader, Annabelle Farrell (BROOKE LANGTON), and her squad of stripper-turned cheerleaders, all as they try to win their games and make it to the playoffs.