It's the 1970s and 13-year-old Cecilia Lisbon (HANNA R. HALL) has just tried to commit suicide in her parents' suburban home. Neither her mother (KATHLEEN TURNER) nor her father (JAMES WOODS) know what to make of this or how to react, and the same holds true for Dr. Horniker (DANNY DEVITO), her psychiatrist, and Cecilia's sisters, 17-year-old Therese (LESLIE HAYMAN), 16-year-old Mary (A.J. COOK), 15-year-old Bonnie (CHELSE SWAIN) and 14-year-old Lux (KIRSTEN DUNST).
Even so, the Lisbons try to get on with their lives. As such, they decide to throw a party and thus invite some of the neighborhood boys over, including Tim (JONATHAN TUCKER), Chase (ANTHONY DESIMONE) and others who are completely enamored by the blond Lisbon sisters.
Unfortunately, the party doesn't help Cecilia who eventually succeeds at her fatal quest and sends her family reeling. It's not until high school football hunk Trip Fontaine (JOSH HARTNETT) decides he wants to ask Lux to the prom -- mainly because she's the epitome of forbidden fruit to him -- that the family finally breaks out of their funk.
Another unexpected turn of events, however, soon has Mr. and Mrs. Lisbon tightening their overprotective reigns over their daughters to an even greater degree. As the near isolation and restrictive environment takes its toll on the sisters, they react in ways that will leave a lasting impression on the boys so taken with them.