Decades ago, the Tenenbaum kids -- Chas (BEN STILLER), Richie (LUKE WILSON) and their adopted sister Margot (GWYNETH PALTROW) - were something to behold. Chas was a natural born businessman who raised and sold Dalmatian mice, Richie was a championship level tennis player, and Margot an award-winning playwright.
Yet, when their neglectful and callous father, Royal Tenenbaum (GENE HACKMAN), left their mother,
Etheline (ANGELICA HUSTON), the kids never quite recovered and became poster children of dysfunctional living. Now 22 years later, things aren't much better, although the family is once again coming together.
When Royal learns that he's being kicked out of the hotel where he's lived ever since then and hears from the family's helper, Pagoda (KUMAR PALLANA), that Etheline is seriously involved with her friend and business manager, Henry Sherman (DANNY GLOVER), the scoundrel decides to insinuate himself back into the family by announcing that he's dying from a terminal disease.
Chas, whose wife died within the past year in a plane accident, has moved his two kids, Ari (GRANT ROSENMEYER) and Uzi (JONAH MEYERSON), into his mom's place after becoming increasingly paranoid about their safety. The perpetually depressed Margot has moved back home after an unhappy marriage to writer and neurologist Raleigh St. Claire (BILL MURRAY), while Richie has returned after traveling the seas lamenting his secret love for Margot. Then there's their childhood friend and current professor and novelist, Eli Cash (OWEN WILSON), who's also maladjusted, what with his drug problem.
As Royal tries to prevent Etheline from marrying Henry, he enlists the aid of his friend, Dusty (SEYMOUR CASSEL), to help him continue his illness ruse so that he can get back into his kids' good graces and thus use them in his plan.