Having grown weary and frustrated with leading a solitary immortal life, the vampire Lestat (STUART TOWNSEND) hoped to sleep away his problems for centuries. Yet, the former 18th century nobleman is awakened by the sounds of the 21st century, and decides to become a star front man for a heavy metal band.
By doing so and flaunting the fact that he's a vampire, he draws the attention of Jesse Reeves (MARGUERITE MOREAU), a researcher at a British institute for paranormal studies whose fascination with vampires stems from having been raised for a while by one, her centuries old aunt Maharet (LENA OLIN). Yet, Lestat's breaking of the vampire code of conduct also brings out his former master, Marius (VINCENT PEREZ), as well as the Queen of all vampires, Akasha (AALIYAH), who's drawn to Lestat's music and ego.
As Jesse tries to get to know and understand Lestat's world, the vampire continues to flaunt his disregard toward other vampires, a point that gets him in trouble with them and only further strengthens Akasha's resolve to rule the world and kill all mortals.