Sean Vetter (VIN DIESEL) and Demetrius Hicks (LARENZ TATE) are undercover DEA agents who've been working for seven years trying to bag Mexican drug lord Guillermo "Memo" Lucero (GENO SILVA). They finally succeed, but not before Lucero tells Vetter that he's made a big and dangerous mistake.
Months later, a new drug lord known only as "Diablo" is staking his claim on the cartels. Unaware of that, Sean has a seaside party with his wife, Stacy (JACQUELINE OBRADORS), Demetrius, boss Ty Frost (STEVE EASTIN), their drug dealer informant, Big Sexy (GEORGE SHARPERSON), and others. That night, gunmen break into the house, seriously injure Sean and mortally wound Stacy.
After recovering from his wounds, Sean not only wants to bring down the latest cartel, but also get revenge on whoever killed his wife. Starting with Big Sexy, he and Demetrius then start working their way up the drug pipeline, including meeting drug dealer Hollywood Jack Slayton (TIMOTHY OLYPHANT). With limited help from Lucero, Sean then sets out to bring down everyone involved in the drug trade, even if it means breaking the law and risking his own life while doing so.