Tomas Fuentes a.k.a. Papi Chulo (EDUARDO VERASTEGUI), is such a good-looking stud that all sorts of women, including his assistant, Mary (JOY ENRIQUEZ), are constantly swooning over him. He has a girlfriend, however, in the shape of Miami cocktail waitress Cici (SOFIA VERGARA).
He can't see her for long, however, since he has to travel to Chicago to see Lorena (ROSELYN SANCHEZ), his other girlfriend, a beautiful lawyer. Then he's off to see rich socialite Patricia (JACI VELASQUEZ) who can't stand her mother constantly fawning over her.
The women aren't aware of the others' existence, but simultaneously decide to travel to Los Angeles to surprise the advertising executive. He's been having progressively worsening anxiety attacks over the three women, and thus mixes alcohol with some prescription tranquilizers, a combination that soon renders him unconscious. But not before all three women descend upon his house, meet each other, and the fur starts flying.
Each is mistrustful of the others, but they join forces when they spot another apparent girlfriend, Carmen (LISA VIDAL), who's wearing a sidearm. They go on the run with the unconscious Tomas in tow, unaware that Carmen is really an FBI agent who's after some stolen money that was in the back of the convertible Cici volunteered to drive to L.A.
The recipients of that money, thugs Rodrigo (D.L. HUGHLEY) and Victor (FREDDY RODRIGUEZ), are none too happy that the women no longer have that money (of which they were unaware). From that point on, and as they await Tomas to regain consciousness and choose between them, the three women go through various gyrations, including posing Lorena as a beauty pageant contestant, as they try to find the money, rescue Tomas and grow as individuals.