In a series of eleven mostly independent vignettes, various characters sit around, drinking coffee, smoking cigarettes and talking about that and other issues in their lives. Roberto (ROBERTO BENIGNI) and Steven (STEVEN WRIGHT) lead off, while a waiter (STEVE BUSCEMI) tries to figure out which of two twins (JOIE LEE and CINQUÉ LEE) is the evil one, while chatting about Elvis and his.
Iggy (IGGY POP) and Tom (TOM WAITS) meet and justify smoking since they've previously quit, while wise-guy Joe (JOE RIGANO) gets on Vinny's (VINNY VELLA) case for smoking and observing the latter's son, Vinny Jr. (VINNY VELLA JR.), who doesn't speak. Renée (RENÉE FRENCH) must deal with a pesky waiter (E.J. RODRIGUEZ) who's determined to fill and thus ruin her perfect cup of coffee, while longtime friends Alex (ALEX DESCAS) and Isaach (ISAACH DE BANKOLÉ) meet and discuss whether anything's wrong.
Movie star Cate (CATE BLANCHETT) takes a break from a press junket to meet her less sophisticated and somewhat envious cousin, Shelly (CATE BLANCHETT), while Jack (JACK WHITE) wants to show Meg (MEG WHITE) an invention he's created.
Alfred (ALFRED MOLINA) wants to tell fellow actor Steve (STEVE COOGAN) that they're related, while GZA (GZA) and RZA (RZA) get on Bill Murray's (BILL MURRAY) case for drinking and smoking. Finally, Bill (BILL RICE) and Taylor (TAYLOR MEAD) shoot the breeze while on a break from work.